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Scientists discover First Natural Human Antibodies against Ebola Virus

A team of scientists from the United States have discovered a possible cure for Ebola viruses. They have discovered the first natural human antibodies that are capable of neutralizing and protecting animals against all three major disease-causing ebola viruses. The findings could lead to the discovery of first effective ebolavirus therapies and vaccines. 

Scientists have discovered the broadly neutralizing antibodies from the blood of a survivor of the 2013-16 Ebola outbreak. Scientists have also pinpointed the human gene which is expected to be the source of the immune cells that produce these antibodies. These antibodies could emerge as a single therapy to treat all Ebola viruses. 

Background

Ebola virus disease (EVD) is a severe, often fatal illness in humans. It was first identified in 1976 in the Democratic Republic of Congo in a village near the Ebola River, from which it takes its name. It is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats are natural host of this virus. It spreads through contact with body fluids of inflected persons such as blood, urine and saliva. Symptoms faced by people who have contracted the Ebola virus include high fever, bleeding and central nervous system damage. In 2014, Ebola virus had erupted periodically mainly across west and east Africa mainly in Guinea, Liberia and Sierra Leone. It was the deadly outbreak of the virus in the history that had killed 11,000 people.

 

 

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New Ebola vaccine may be up to 100% effective: WHO

The World Health Organization (WHO) has expressed confidence that a prototype vaccine for Ebola called rVSV-ZEBOV may be 100% effective in protecting against the deadly virus.

The vaccine was initially developed in Canada by public health authorities before being taken over by pharmaceutical giant Merck.

Key Facts
  • Earlier in a major experimental human clinical trial of this vaccine conducted on nearly 6,000 people in Guinea in 2015 was found to successfully.
  • It was observed that no one from the 6,000 people contracted again to the lethal disease. The test results of the trial were released in The Lancet magazine.
  • This new vaccine has not yet been approved by any regulatory authority. But it is said that the vaccine could become available in 2018 under a fast-track approval process.
  • However, this new vaccine has some flaws as it appears to work against only one of the two most common strains of the Ebola virus.
  • Thus, it may not give long-lasting protection and some of patients who were given this vaccine have reported side effects like joint pain and headaches.

About Ebola virus

Ebola virus disease (EVD) is a severe, often fatal illness in humans. It was first identified in 1976 in the Democratic Republic of Congo in a village near the Ebola River, from which it takes its name. It is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats are natural host of this virus. It spreads through contact with body fluids of inflected persons such as blood, urine and saliva. Symptoms faced by people who have contracted the Ebola virus include high fever, bleeding and central nervous system damage. In 2014, Ebola virus had erupted periodically mainly across west and east Africa mainly in Guinea, Liberia and Sierra Leone. It was the deadly outbreak of the virus in the history that had killed 11,000 people.

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