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First malaria vaccine to be tested in Kenya, Ghana and Malawi in 2018

The World Health Organization has announced that it is ready to test the first malaria vaccine in the real world setting in 2018. The aim of the testing will be to ascertain whether the vaccine will work under real world circumstances or not. Kenya, Ghana and Malawi have been chosen for taking part in the pilot project.

The vaccine, RTS,S, also known as Mosquirix, was produced by GlaxoSmithKline in 1987 in a public-private partnership with the PATH Malaria Initiative and with support from the Bill and Melinda Gates Foundation. In 2015, the vaccine received approval from the European Medicines Agency (EMA).

For the next four years (2017-2021), the vaccine will be administered to children between 5 and 17 months in Kenya, Ghana and Malawi. The vaccine will be given four times and will be administered by an intramuscular injection.

The RTS, S vaccine works by targeting the liver phase of the malaria parasite’s life cycle as the parasite multiplies inside the liver after getting introduced into the body by a mosquito bite. It has taken about 30 years for the creation of the vaccine to the approval of pilot programme in 2017. Only five species of Plasmodium parasite spread malarial parasite worldwide.

Need

According to WHO, malaria kills one child every two minutes and has killed 429,000 people in 2015. According to the WHO World Malaria Report 2016, Nigeria suffers most malaria deaths worldwide (26%), followed by the Democratic Republic of Congo (10%), India (6%), and Mali (5%). African continent suffers the most mosquito-borne ailments and there still exists gaps in prevention coverage as many people in sub-Saharan Africa lack access to mosquito protection like bed nets or bug spray.

 

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Ghana’s proposal of land to Punjab farmers accepted by Punjab Government

The Punjab Government has agreed to the Ghana Government’s proposal offering land to Punjab farmers. As per the proposal, the government of Ghana would provide fertile farmland on a long-term lease to Punjab farmers for farm activities. Ghana has made this proposal to promote agriculture as a tool of progress in Ghana and if possible then by Punjab’s expertise in farming.

Punjab Government has assured Ghana that a high-level delegation of officers as well as an expert from Punjab Agricultural University (PAU), Ludhiana, would be sent to Ghana to study the suitability of the entire project.

Ghana also offered Punjab to export finished goods to Ghana. It has invited Punjabi entrepreneurs to visit Ghana to start manufacturing facilities in the country and take advantage of Ghana’s natural resources like various minerals, timber, oil, cocoa, palm oil fish and cotton.

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RTS,S: World’s first vaccine against Malaria to hit markets soon

The world’s first malaria vaccineRTS,S created by pharma company GSK, is expected to hit the markets by 2015. GSK has submitted a regulatory application to the European Medicines Agency (EMA) for its malaria vaccine candidate, RTS,S.

Application of RTS,S:

The vaccine will be uses exclusively against the Plasmodium falciparum malaria parasite, which is widespread in Sub-Saharan Africa (SSA). As per estimates, around 90% deaths from malaria occur in SSA, and 77% of these are in children under the age of 5.

To support the efficacy of the vaccine, data from the phase III vaccine trial programme conducted at 13 African research centres in eight African countries (Burkina Faso, Gabon, Ghana, Kenya, Malawi, Mozambique, Nigeria, and Tanzania) including over 16,000 infants and young children have also been included to the filing. A large-scale Phase III trial showed that over 18 months of follow-up, children aged 5-17 months at first vaccination with RTS,S reported 46% fewer cases of clinical malaria, compared to children immunised with a placebo.

An average of 941 cases of clinical malaria were prevented over 18 months of follow-up for every 1,000 children vaccinated in this age group. Malaria hospitalisations came down by 42%.

How RTS,S works?

The vaccine triggers the body’s immune system to protect against the P falciparum malaria parasite when it first enters the human host’s bloodstream and/or when the parasite infects liver cells. The vaccine is developed to prevent the parasite from infecting, maturing and multiplying in the liver, after which time the parasite would re-enter the bloodstream and infect red blood cells, leading to disease symptoms.

GSK has pledged to sell the vaccine at cost price plus 5%, which it said would finance further research into tropical diseases. Now EMA will evaluate the vaccine as per Article 58 procedure, which allows the body to assess the quality, safety and efficacy of a candidate vaccine, or medicine, manufactured in a European Union (EU) member state, for a disease recognised by the World Health Organisation as of major public health interest, but intended exclusively for use outside the EU.

This assessment is conducted by the EMA in collaboration with the WHO, and necessitates products to meet the same benchmarks as vaccines or medicines intended for use in the EU.  As per WHO, if the EMA approves the vaccine, a policy recommendation may be possible by end of 2015.  A positive opinion from the EMA would also be the basis for marketing authoritization applications to National Regulatory Authorities (NRAs) in SSA nations.

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