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Scientist a synthetic molecule to quell allergy

Scientists have discovered that a new synthetic molecule named “DARP E2-79” could pave the way for quick-acting remedies for a number of acute allergic reactions.

What is Allergy?

Allergy is a hypersensitivity disorder of immune system. These reactions occur when a person’s immune system  reacts to normally harmless substances in the environment. The substance which incites such a reaction is called an allergen. These reactions are acquired, predictable, and rapid. When exposed to the allergen, the immune system produces a type of antibody (IgE). IgE incites certain cells in our body (mast cells and basophils) to produce chemical called histamine. Histamine is what is responsible for the symptoms of your allergy.

How can “DARP E2-79” help?

In order to trigger an allergic response, antiboby IgE needs to bind with a specific receptor called FcR. FcR is a protein found on the surface of certain cells including mast cells, immune cells present in the nasal lining and in the eyelids, along with IgE. Here works DARP E2-79, which detaches IgE from its partner FcR, thereby turning the process off.

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New Gene Therapy Method to prevent certain genetic diseases tested

Researchers have devised a method that will prevent certain genetic diseases from passing from mother to child.  The technique prevents the transfer of defective DNA from the mitochondria of the mother egg cell to child.

What is the method?

In this therapy the firstly, nucleus of the mother’s as well as the donor’s egg is removed. Then mother’s nucleus is transferred into the nucleus deficient donor’s egg. By doing this DNA defects arising from mitochondrial genetic material of the mother can be avoided. The egg is then fertilized by the sperm and then it is replanted into the mother and develops a healthy baby. 

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Resistin

Scientists discover that Resistin is main agent behind high cholesterol levels

Scientists have established a link b/w a protein “Resistin” and high levels of bad cholesterol. The have found that Resistin released by fat tissue causes elevated levels of "bad" cholesterol (low-density lipoprotein or LDL), which in turn increases the risk of heart ailments.

What is Resistin?

Resistin is a cysteine-rich protein. It is also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1). Resistin was discovered in 2001 by the group of Dr Mitchell A. Lazar from the University of Pennsylvania School of Medicine. It was named "resistin" because it showed resistance to insulin when it was injected in mice.

How Resistin affects cholesterol levels?

As per the research, resistin increases the production of LDL in liver cells and also degrades LDL receptors in the liver. Due to this, the liver is less able to remove "bad" cholesterol from the body. Resistin speeds up the accumulation of LDL in arteries thus increases the risk of heart disease.

It was also found that resistin adversely impacts the effects of statins, the main cholesterol-reducing drug used in the treatment and prevention of cardiovascular disease.

How high cholesterol level in blood becomes problematic?

High blood cholesterol leads to a buildup of plaque around the artery walls and narrowing of the arteries, developing into a condition called atherosclerosis, which can make it more difficult for blood to flow through the heart and body.

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