Researchers from Indian Institute of Technology (IIT) Roorkee have identified two small potent molecules Pep-I and Pep-II, for their inhibitory activity to treat Chikungunya disease. The antiviral activity of these molecules was so high that their small amount was able to achieve almost 99% reduction in virus. Currently, there are no drugs to treat chikungunya or any vaccine to prevent it.
The antiviral activity was tested by adding molecules directly into virus culture. Using structure-based studies of chikungunya virus-specific nsP2 protease, researchers had identified two small molecules Pep-I and Pep-II for their inhibitory activity against vector borne disease.
Protease inhibitors have already been used successfully against HIV and hepatitis C virus. Pep-I, one of two molecules has superior antiviral activity against chikungunya virus. It was found to effectively bind to protein of virus (nsP2 protease) and prevent virus from replicating. It is hypothesised that any molecule that inhibits nsP2 protease is having antiviral activity.
During studies it was confirmed that both molecules have significant ability to kill virus. Pep-I molecule was very efficient in killing the virus, 99% reduction in virus at 5 microMolar and Pep-II molecule showed reduced antiviral activity of only 50% even at a higher concentration of about 200 microMolar. The two molecules also reduced viral RNA thus confirming the antiviral activity.
Chikungunya is a mosquito-borne virus that causes a disease. It is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Its symptoms are characterised by abrupt fever and severe joint pain, often in hands and feet, and may include headache, muscle pain, joint swelling or rash.
There is no specific antiviral drug treatment for chikungunya. There is no commercial vaccine to treat chikungunya. Chikungunya treatment is directed primarily at relieving the symptoms, including the joint pain using anti-pyretics, optimal analgesics and fluids.
Month: Current Affairs – April, 2018 Categories: Science & Technology
Tags: Antiviral Activity • Chikungunya • Diseases • IIT Roorkee • Pep-I • Pep-II • Science and Technology
The Union Cabinet has approved promulgation of Criminal Law (Amendment) Ordinance to provide death penalty for rapists of girls below 12 years. The ordinance amends Indian Penal Code (IPC), Criminal Procedure Code, Protection of Children from Sexual Offences (POCSO) Act and Indian Evidence Act.
Key Provisions of Ordinance
It provides for stringent punishment of jail term of minimum 20 years or life imprisonment or death for rape of girl less than 12 years. It provides punishment with imprisonment for rest of life or death sentence in case of gang rape of girl below 12 years.
It increases minimum punishment from 10 years to 20 years for crime of rape of girl under 16 years, which can be extended to imprisonment for rest of life. It increases minimum punishment for rape of women from rigorous imprisonment of 7 years to 10 years, which can be extended to life imprisonment.
It provides for speedy investigation and trial, which must be completed in two months. It proposes 6 months’ time limit for disposal of appeals in rape cases. It provides dedicated manpower for investigation of rape cases in time bound manner.
It provides no provision for anticipatory bail for person accused of rape or gang rape of girl under 16 years. It has also been provided that court has to give notice of 15 days to Public Prosecutor and representative of victim before deciding bail applications in case of rape of a girl under 16 years of age.
It has provision for maintaining national database and profile of sexual offenders by National Crime Records Bureau (NCRB). This data will be regularly shared with States/UTs for monitoring, tracking and investigation including verification of antecedents by police.
Month: Current Affairs – April, 2018 Categories: Constitution & Law
Tags: Bills and Acts • Cabinet Decisions • Criminal Law (Amendment) Ordinance • National • Ordinances