Effectiveness of Medication is Gene-dependent: Research; that’s why a particular drug is effective for certain people but not for others.
A new research attempts to answer why a particular drug is effective for certain people but not for others. The research team has found that genes play a significant role. Scientists have generated a database associating 145 genetic regions with more than 400 molecules involved in metabolism in human blood. This compendium of genetic links with metabolism provides many new opportunities to understand the molecular pathways underlying associations with common, complex diseases.
Metabolic molecules, known as metabolites, include a wide range of different molecules such as vitamins, lipids, carbohydrates and nucleotides. They constitute parts of, or are the products of, all biological pathways.
This new database of associations between genetic regions and metabolite levels provides a powerful tool to identify genes that could be used in drug and diagnostic tests for a wide range of metabolic disorders. It will help in drug discovery for metabolic disorders and also facilitate scientists to understand the biology behind disease.