Chronic Respiratory Disease Current Affairs - 2020

COVID-19 culture for vaccine development and drug testing

The Centre for Cellular and Molecular Biology cultured COVID-19 from the patients infected with the virus.

Highlights

The virologists at CCMB will isolate infectious virus from the patients. The isolated virus will be used for vaccine development and drug testing.

Significance

Virus Culture is important for development of antibodies. The inactivated virus when injected into human bodies will trigger antibody responses. The antibodies generated are processed, collected and purified and used for therapeutic intervention.

The cultured virus also helps in the process of drug screening.

Status of the study

Under the study, the researchers of CCMB are to produce large quantities of COVID-19. The researchers will also test potential drugs with partners such as DRDO (Defence Research Development Organization).

Challenges

COVID-19 enters human cell through ACE-2 receptor. The respiratory disease in the case of COVID-19 is caused in respiratory tract and mainly is because of the infection caused in epithelial cells. However, epithelial cells cannot be grown in the lab.

Pranavayu Programme launched in Karanataka

The Bengaluru City Corporation recently launched “Pranavayu Programme” to create awareness about the respiratory health of Bengaloreans.

Highlights

The initiative aims to help people in increasing oxygen level of the people by themselves. This will help them to keep track about their health before their ailments become fatal.

Significance

There are several deaths reported in the country due to Severe Acute Respiratory Illness (SARI). Especially, COVID-19 causes Hypoxia (deficiency of oxygen in tissues). This is like starving the body of oxygen.

COVID-19 and breathing problems

COVID-19 stimulates breathing difficulties through chemical reactions. When a person is infected with COVID-19, the virus binds itself with the haemoglobin in Red Blood Cells. This is the main reason for disruption in respiratory process.

During normal respiration, the haemoglobin acts as a carrier of oxygen from the air chambers in lungs to the cells all over the body. In return they collect carbon dioxide from these cells and carry it to the lungs.

COVID-19 blocks the functioning of haemoglobin that causes breathing difficulty.