Pharmaceuticals Current Affairs - 2019

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Chinese scientists discover XMU-MP-1 molecule to repair organs

Chinese scientists have discovered a small molecule (new drug) named XMU-MP-1 that can regenerate tissue. It has potential to eliminate transplants of some organs.

It was discovered by team of researchers from Xiamen University and  Peking University of China. The findings were published in Science Translational Medicine.

Key Facts

  • The drug, XMU-MP-1 can promote repair and regeneration in the liver, intestines and skin.
  • It was found that it has ability to inhibit the activity of two enzymes MST1 and MST2, the central component of this pathway which normally prevent cells from proliferating.
  • By inhibiting the activity of MST1/2, XMU-MP-1 can promote cell growth in four different mouse models with acute injuries.
  • For this research purpose, researchers had specifically targeted a critical signalling molecule in the Hippo pathway, which controls organ size and growth.

Significance: This study paves the way for medicines that help to rebuild organs instead of relying on complicated therapeutic strategies such as regenerative cells to specific spots and delivering biomaterials in the body to repair and restore injured tissue.

Cabinet Committee on Economic Affairs (CCEA) approved Rs.1750 crore for strengthening the drug regulatory system

The Cabinet Committee on Economic Affairs (CCEA) has approved Rs.1750 crore for strengthening the drug regulatory system both at the Central and the State.

The sanctioned amount will be spent for strengthening and up-gradation of the drug regulatory system over a period of three years.

The total amount of Rs 1750 crore will be divided into two parts, an amount of Rs.900 crore will be spent on strengthening central structures whereas Rs.850 crore will be made available to the State Governments.

Strengthening and up-gradation includes:

  • Provision of additional equipment and manpower in existing drug testing laboratories
  • Setting up of new laboratories for testing drugs, medical devices and cosmetics
  • Making mobile drug testing laboratories available
  • Creation of additional manpower for regulatory structures.
  • Introduction of organisation wide e-Governance and Information Technology enabled/ online services.
  • Setting up a training academy for both the Central and State regulatory and drug testing officials.
  • Assistance to the States for strengthening their drug regulatory structures.

The need for strengthening and up-gradation of drug regulatory system was felt in line with recent ban imposed by US and EU on drugs manufactured in India.


  • These measures will help Indian drug manufactures to enhance quality, safety and efficacy of drugs and other medical products.
  • This will also help to increase export of pharmaceutical products from India and thus will trigger growth of the domestic medical devices sector.
  • The measure of common training programmes for regulatory and laboratory staff will help to develop uniform practices throughout the country.

Note: India is one of the largest manufacturers of drugs and exports pharmaceutical products to over 200 countries/economies.